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South San Francisco or the “Industrial City” as its spelled out by the iconic Sign Hill located on San Bruno Mountain was the center of the meatpacking industry. Today it is home to a thriving biotechnology industry, with many biotech companies having their headquarters or research facilities in the city. It is sometimes referred to as the "Birthplace of Biotechnology," as Genentech, the first biotechnology company, was founded there in 1976.

In addition to biotechnology, South San Francisco is also known for its beautiful parks and recreational opportunities. The city has over 20 parks, including Orange Memorial Park, which features a swimming pool, tennis courts, a playground, and picnic areas.

South San Francisco has a moderate Mediterranean climate, with mild winters and cool summers.